Professor Macoska is the Alton J. Brann Endowed Chair and Distinguished Professor of Science and Mathematics at the University of Massachusetts Boston. Prior to that (1994-2012) she was Professor of Urology and Associate Director of the Graduate Program in Cellular and Molecular Biology and faculty in the Programs in Cancer Biology and Department of Computational Medicine and Bioinformatics at the University of Michigan. She also served as Associate Director, Prostate/Urologic Oncology Program, University of Michigan Comprehensive Cancer Center and is a past President of the Society for Basic Urologic Research. Professor Macoska has led peer-reviewed and funded research for >20 years that is focused on elucidating the molecular genetic alterations and dysfunctional inter- and intra-cellular signaling mechanisms that promote prostate pathobiology.
Research in the Macoska laboratory is currently focused on:
1) Defining the mechanisms through which dysfunctional paracrine interactions between diverse cell types – epithelial, fibroblastic, endothelial, leukocytic – develop consequent to the aging process, and how these dysfunctional interactions contribute to the development of benign and malignant disease;
2) Elucidating the intracellular mechanisms through which growth factors, particularly CXC-type chemokines, secreted by aging stromal fibroblasts and inflammatory cells stimulate cellular proliferation and myofibroblast phenoconversion, and the association of these pathobiologies, particularly tissue fibrosis, with organ dysfunction and malignancy;
3) Understanding the similarities and differences between disease pathobiologies to better stratify patients for appropriate treatment strategies; and
4)Translating laboratory-based knowledge to the development of clinically efficacious biomarkers and therapeutics.